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📙 Chemical Biology: Approaches to Drug Discovery and Development to Targeting Disease by — free download


An authoritative look at the application of chemical biology in drug discovery and development

Based on the award-winning Wiley Encyclopedia of Chemical Biology published in 2008, this book explores the role of chemical biology in drug discovery and development. The first part of the book reviews key principles and techniques used in the design and evaluation of drug candidates. The second part elucidates biological mechanisms of certain diseases, illuminating approaches to investigate and target these diseases.

Comprising carefully selected reprints from the Encyclopedia as well as new contributions from leading scholars in the field, this book provides researchers in academia and industry with important information to aid in the development of novel agents to treat disease. Self-contained articles cover a variety of essential topics, including:

  • The design, development, and optimization of drug candidates
  • The pharmacokinetics and properties of drugs
  • Drug transport and delivery
  • Natural products and natural product models as pharmaceuticals
  • Biological mechanisms underlying health and disease
  • Treatment strategies for a range of diseases, from HIV to schizophrenia

Chemical Biology is a top-notch guide and reference for anyone working in the areas of drug discovery and development, including researchers in chemical biology and other fields such as biochemistry, medicine, and pharmaceutical sciences.Content:
Chapter 1 The Role of Chemical Biology in Drug Discovery (pages 1–21): Andrew J. Pope
Chapter 2 Computational Approaches to Drug Discovery and Development (pages 23–40): Honglin Li, Mingyue Zheng, Xiaomin Luo, Weiliang Zhu and Hualiang Jiang
Chapter 3 Design and Selection of Small Molecule Inhibitors (pages 41–63): Jianwei Che, Yi Liu and Nathanael S. Gray
Chapter 4 Lead Optimization in Drug Discovery (pages 65–81): Craig W. Lindsley, David Weaver, Thomas M. Bridges and J. Phillip Kennedy
Chapter 5 Pharmacokinetics of Drug Candidates (pages 83–100): Ronald E. White
Chapter 6 ADME Properties of Drugs (pages 101–114): Li Di and Edward H. Kerns
Chapter 7 Drug Transport in Living Systems (pages 115–132): Yael Elbaz and Shimon Schuldiner
Chapter 8 Blood?Brain Barrier: Considerations in Drug Development and Delivery (pages 133–146): David S. Miller and Brian T. Hawkins
Chapter 9 Pharmacokinetic Considerations: Methods and Systems of Controlled Drug Delivery (pages 147–164): Zhong Zuo and Vincent H. L. Lee
Chapter 10 Pharmaceuticals: Natural Products and Natural Product Models (pages 165–201): Sheo B. Singh
Chapter 11 The Role of Chemical Biology in Understanding and Treating Disease?Are Small Molecule “Correctors” the Way of the Future? (pages 1–214): David Selwood
Chapter 12 Anxiety Disorders (pages 215–243): Miklos Toth
Chapter 13 Chronic Obstructive Pulmonary Disease (COPD) (pages 245–265): Peter J. Barnes
Chapter 14 Depression (pages 267–292): Glen B. Baker and Nicholas D. Mitchell
Chapter 15 Osteoarthritis (pages 293–329): Marjolaine Gosset, Jeremie Sellam, Claire Jacques and Francis Berenbaum
Chapter 16 Human Immunodeficiency Virus (HIV) (pages 331–339): Joseph P. Vacca
Chapter 17 Allergy and Asthma (pages 341–355): Garry M. Walsh
Chapter 18 Schizophrenia (pages 357–378): Ferenc Martenyi
Chapter 19 Protein Misfolding and Disease (pages 379–400): Johanna C. Scheinost, Grant E. Boldt and Paul Wentworth
Chapter 20 Protein Trafficking Diseases (pages 401–417): Heidi M. Sampson and David Y. Thomas
Chapter 21 Metabolic Diseases (pages 419–443): Cynthia M. Arbeeny
Chapter 22 Mitochondrial Medicine (pages 445–460): Richard J. T. Rodenburg and Jan A. M. Smeitink
Chapter 23 Lysosomal Disorders (pages 461–481): Doug A. Brooks and Maria Fuller

About book:

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  • Year: 2012
  • Language: English
  • ISBN: 9781118101186,9781118435762

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  • File size: 4 330 592
  • Format: pdf


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